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Proven Treatments for Hormone
Refractory Prostate Cancer
There are three general categories of
treatments for men with hormone refractory prostate cancer and one covering
"other" that are less recognized as HRPC treatments. These are:
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Second-line
hormonal therapies. Ketoconazole, estrogens and more ("other" below, can
also be considered 2nd-line hormone therapies.)
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Chemotherapy.
This is an extensive set of papers and tables covering use with HRPC.
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Radiation.
Covered here are spot radiation, radiopharmaceuticals and more.
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Other. Treatments covered here are ones that
HRPC patients might want to investigate further. Treatments that have had some
clinical trials data where PSA or other response rates have been published,
but are lower than one would want or treatments that only shown a lengthening
of PSA doubling time or delayed progression as manifested by a PSA
decline less than the 50% criteria normally used. Treatments that fall into
this category are using leukine (gm-csf), leukine and retinoids, leukine and
thalidomide, leukine and ketoconazole, somatostatin analogs(e.g. Sandostatin
LAR, dutasteride (Avodart®) and nilutamide. A new addition is the combination
of leukine and Revlimid (lenalidomide.)
Potential/possible uses for "other" are:
H.Hansen 3/18/2007
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