Home
Up
What's New
News
What To Do First
On Line Support List
Proven Treatments
Potential Treatments
Diagnostic Tests
Information Resources
FAQ

 

 


Click Here to Return to Side Effects and Symptoms Management
 

Low Blood Counts

While on chemotherapy, your oncologist will be monitoring your blood counts with a complete blood count (CBC).  Most often checked are the white blood cell count (WBC), the absolute neutrophil /granulocytes count (ANC, GRAN or GR#), the red blood cell count along with the hemoglobin and hematocrit.  ANC is important as it is the component of the WBC that fights infection.  Hemoglobin is important as a low level indicates anemia and contributes to a feeling of fatigue. Platelets are the third item looked at and a low platelet count is termed thrombocytopenia.

A low WBC/ANC can be treated using drugs such as Neulasta or Neumega or Leukine.  Low Hemoglobin/low hematocrit can be treated with drugs such as Procrit and Aranesp.  Low Platelets or thrombocytopenia lacks bone marrow supportive drugs (there is a drug currently on the market, but most oncologists are reluctant to use it due to side effects).  Therefore, current therapeutic options are mostly palliative, including steroids, immunosuppresants, splenectomy and, for the most severe thrombocytopenias, platelet transfusion.

Sometimes treatment is delayed while waiting for platelets to recover.  Also, the dose of chemotherapy can be lowered. Some new drugs are in the pipeline.  Phase I clinical trials of LGD 4665, an oral, small molecule drug that mimics the activity of thrombopoietin (TPO), a growth factor that promotes growth and production of blood platelets have been started. Another drug called, AKR-501 is starting phase II.  There are others as well. 

To see a graph of WBC(white blood count) and GRAN(granulocytes) and how they are impacted by weekly single agent taxotere and by Novantrone (every 3 weeks), click here.

Low Blood Counts Excerpt from the booklet "Choices"

This section is an excerpt of an excellent booklet called "Choices: Living with cancer, dying with dignity." Molly Sower Sugarman wrote this booklet in honor of her husband, Matthew, who died of prostate cancer in 1999. The Rotary Clubs of District 5190, generously funded the publication of this brochure. Molly and the Rotary Club have given permission to reprint this section. You can obtain a complete copy of the brochure by sending an e-mail request to Molly at mssugarman@gmail.com or by reading the copy at the PSA-Rising website.


INTRODUCTION

If cancer affects your bone marrow, the marrow will produce fewer and fewer of the blood cells essential to your well being.

Too few red blood cells causes fatigue and breathlessness. The bone marrow produces red blood cells, which carry oxygen. With too few red blood cells, your body does not have enough oxygen. Giving you oxygen may not be a solution. It is not lack of oxygen intake that is causing the problem; it is lack of cells to carry the oxygen.

Low white-cell counts increase your risk of infection. Too few platelets reduces the ability of blood to clot.

Low blood counts may be caused by treatment, such as radiation. The effects on your bone marrow may wear off over time and the cell counts may go up again. Low blood counts may also result when cancer destroys the cell-making capacity of the bone marrow or when the cancer kills blood cells faster than the marrow can make new ones.

If the cancer has destroyed the bone marrow’s ability to produce blood cells, palliative measures are available to help maintain your quality of life but these measures will not cure the problem.

PALLIATIVE MEASURES

If blood counts are low due to treatments, such as radiation, medication may "jump start" the bone marrow. Usually the medicine is given in a series of injections. You may be able to give the injections yourself. If this is successful, the blood counts will rise and the symptoms—breathlessness and fatigue—may lessen.

Eventually, the toxic effect of the cancer on all body systems may increase, making fatigue and breathlessness unavoidable. You may be less able to perform daily tasks simply because you don’t have the energy.

Blood transfusions can increase the number of red blood cells available to carry oxygen. Your doctor can test your blood on a regular basis and, if the cell counts are low, order the transfusion of whatever amount of blood he or she feels will reduce your fatigue.

Because the bone marrow is not replenishing the red cells naturally, this outside replenishment may be ordered repeatedly, on a monthly or more frequent basis, as needed. When blood transfusions are required frequently, you may want to consider whether the time spent traveling to the medical center and getting the treatment is worth the benefit received. This is one of the many choices you have to make between treatment and quality of life.

Ask your doctor about options to minimize the effects of low blood counts or what help hospice care might offer.

LIFESTYLE CONSIDERATIONS

Techniques for dealing with the fatigue and the breathlessness of low red blood counts are discuss in the section "Fatigue."

White blood cells cannot be transfused. Because of the increased risk of infection when white counts are low, your doctor may suggest immunizations for flu and pneumonia, or avoiding people who have contagious diseases. You will want to pay attention to health alerts aimed at people with reduced immune systems. Report any fever to your doctor for early antibiotic therapy, if needed.

Low platelet counts may cause problems with clotting and reduce the body’s ability to stop bleeding, even from minor cuts and scrapes, such as those that occur while shaving. Tell your doctor about any sign of bleeding, such as a nosebleed or blood in your urine or stool.

You may bruise more easily. If this happens, you may want to talk to your doctor about medicines, food or herbs that increase the clotting ability of blood.

Molly Sower Sugarman

 

 

 

This information is provided for educational purposes only and does not replace or amend professional medical advice. Unless otherwise stated and credited, the content of www.hrpca.org is by and the opinion of and copyright © 2001-2008 by H. Hansen. All Rights Reserved.  Our policy regarding privacy,  right to reprint and contact information are at About Us. We are a 501(c)(3) not-for-profit public charity.